• Pain relievers are sometimes called for in liberal doses. Narcotics may have excessive side effects, however, because they are metabolized by the liver, which may not be functioning properly. • Non-steroidal anti-inflammatory drugs may be effective even against the severe pain associated with metastatic cancer. • The loss of appetite that often accompanies metastatic cancer may be relieved with a medication called Megace . • The use of water pills to alleviate fluid in the abdomen or legs may cause a significant imbalance in kidney function, creating major problems if their use is not carefully monitored. • Nausea can be adequately treated with standard medications, including suppositories. • Sleep disturbances are common, but sleeping pills (sedatives) should be used carefully, since most are metabolized by the liver.